antitumor effect — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T19675	SM360320	CL-087,SM 360320,CL 087,1V136,SM-360320,CL087	TLR
	SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ...		TLR
T17731	CL2A-SN-38		Others
	CL2A-SN-38 is a drug-linker conjugate consisting of SN-38, a potent DNA topoisomerase I inhibitor, and linker CL2A, for the manufacture of antibody drug conjugates (ADCs). CL2A-SN-38 provides significant and specific ant...		Others
T7049	Herniarin	Methyl umbelliferyl ether,Ayapanin,7-Methoxycoumarin,Herniarine	Others
	Herniarin (Ayapanin) is a natural coumarin with antitumor effect.		Others
TN1576	Diallyl disulfide		IL Receptor , NOS , NF-κB
	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.		IL Receptor , NOS , NF-κB
T23867	Cdc7-IN-7c	Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c	CDK
	Cdc7-IN-7c (Cdc7 inhibitor-7c) has antitumor activity and has inhibitory effect on liver cancer, lung cancer, kidney cancer, brain cancer and cervical cancer.		CDK
TN1490	Chrysoeriol		ERK , p38 MAPK , Akt
	Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect.		ERK , p38 MAPK , Akt
T77551	6'-hydroxydihydrocinchonidine		Antibiotic , Drug Metabolite
	6'-hydroxydihydrocinchonidine is a metabolite of quinine, with antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococcus pneumoniae.		Antibiotic , Drug Metabolite
T1257	Bestatin	Ubenimex	Others , Aminopeptidase , Antibacterial , Antibiotic , LTR
	Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Amin...		Others , Aminopeptidase , Antibacterial , Antibiotic , LTR
T11108	DSR-6434		TLR
	DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.		TLR
T77688	Dipotassium tetrachloroplatinate	Potassium tetrachloroplatinate	Others
	Dipotassium tetrachloroplatinate (Potassium tetrachloroplatinate) exhibits antitumor activity in solid tumor lines and can be used in the treatment of oncological diseases. Dipotassium tetrachloroplatinate also acts as a...		Others
T6S0052	Chelerythrine	Toddalin,Broussonpapyrine,Cheleritrine	Apoptosis , BCL , PKC , Autophagy
	1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera...		Apoptosis , BCL , PKC , Autophagy
T21593	AAL-993		VEGFR
	AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni...		VEGFR
T13416	ZX-29		ALK
	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.		ALK
T4S1999	Valepotriate	Valtrate	Apoptosis , HIV Protease
	Valepotriate (Valtrate) fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agen...		Apoptosis , HIV Protease
T3386	Kaempferitrin	Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside	cell cycle arrest , Glucokinase , IGF-1R
	Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucos...		cell cycle arrest , Glucokinase , IGF-1R
T3142	Drostanolone Propionate		Others
	Dromostanolone propionate (Drostanolone propionate) is a compound that has antitumor activity against breast carcinoma [1]. Dromostanolone propionate inhibits the uptake of oestradiol-17 by the tumor without apparent eff...		Others
T3822	Bellidifolin	Bellidifoline,Bellidifolium	Others , HIV Protease
	Bellidifolin (Bellidifoline) has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms rela...		Others , HIV Protease
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
T26644	Apomine	SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A	HMG-CoA Reductase
	Apomine (SR-9223i), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylg...		HMG-CoA Reductase
T3317	SZL P1-41		Apoptosis , Others , E1/E2/E3 Enzyme
	SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...		Apoptosis , Others , E1/E2/E3 Enzyme